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Emphasis is being placed on the private sector because procu
2019-04-29

Emphasis is being placed on the private sector because procurement is largely driven by anticipated sales volumes and profit margins. Unlike the public sector, where the centralised nature of commodity procurement and service delivery mechanisms makes it rac1 inhibitor simpler to achieve adherence
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SCN A encodes for the subunit of
2019-04-29

SCN5A encodes for the α subunit of the cardiac sodium channel, and SCN5A mutations are found in 11–28% of clinically diagnosed BrS patients [11]. Since 1998, genetic variants in over 10 genes have been reported in patients with BrS. Table 1 lists these genes, the mutation locations, and the function
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Introduction Ewing s sarcoma ES is a high grade
2019-04-29

Introduction Ewing\'s sarcoma (ES) is a high-grade neoplasm representing the second most common primary bone malignancy in both children and adults. With a peak incidence at 15 years, this disease accounts for 2% of childhood cancers [1–3]. ES is defined as a bone tumor which may occur at any site
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Antzelevitch and colleagues have long suggested
2019-04-29

Antzelevitch and colleagues have long suggested an alternative explanation [31,73,74]. Loss of the procyanidin b2 (AP), which has been shown in experimental models to create the arrhythmogenic substrate in BrS, leads to contractile changes that could explain the wall motion abnormalities observed. T
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Desde el punto de vista de Antileo el camino hacia
2019-04-29

Desde el punto de vista de Antileo el camino hacia la liberación no debiera establecer una división descalificadora de las luchas y acciones de los mapuche que han salido de las comunidades, pues el radicalismo que cuestiona su legitimidad por estar fuera de ellas no permite verlos como agentes de r
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Selumetinib br Conflict of interest br Introduction T cell p
2019-04-29

Conflict of interest Introduction T-cell prolymphocytic leukemia (T-PLL) is a rare type of peripheral T-cell leukemia with a naive T-cell phenotype [1]. The clinical features of T-PLL include marked hepatosplenomegaly and generalized lymphadenopathy with rapidly progressive lymphocytosis. The
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For many decades scientists have warned that human
2019-04-29

For many decades, scientists have warned that human activity is pushing life on our planet beyond the point of no return. In the Earth\'s history there have been five mass extinction events, most recently the Cretaceous–Tertiary mass extinction that occurred almost 65 million years ago and was thoug
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We would like to invite Kruk and
2019-04-29

We would like to invite Kruk and colleagues to provide any information they may have about whether the women attending the primary or secondary health facilities to give birth were at low risk or high risk of complications during delivery. It could be that women who would be considered to be at high
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Desde este punto de vista asume una perspectiva
2019-04-28

Desde este punto de vista, asume una perspectiva “técnico-económica” que es la que le da soporte a su definición de diversidad cultural y que justifica su postura a favor de la universalidad de los derechos humanos, en tanto que considera injusto que algunos grupos humanos sean destinados a permanec
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br Proyecto Sistema Acu fero Guaran El
2019-04-28

Proyecto Sistema Acuífero Guaraní El agua en sus distintas formas ha sido considerada por los pueblos como fuente de riqueza, desarrollo y poder. Han sido compartidas pacíficamente y también se han convertido en puntos de conflictos. En este apartado se revisa brevemente el Proyecto Sistema Acuíf
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In Giovanni Forzieri and colleagues present the
2019-04-28

In , Giovanni Forzieri and colleagues present the future effects of the seven most harmful weather-related extreme events in Europe due to climate change. These seven events are heatwaves, cold waves, droughts, wildfires, river and coastal floods, and windstorms. They estimated the occurrence and in
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br In March the United Nations Statistics
2019-04-28

In March, 2016, the United Nations Statistics Commission agreed upon the metrics used to measure progress towards, or away from, the new Sustainable Development Goals (SDGs). These so-called indicators define the real-world, measurable counterparts to the targets within the visionary goals of the
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Almost all the information we have on clinical
2019-04-28

Almost all the information we have on clinical epidemiology of patients with d-glucose failure is collected in North America or in western European countriesTherefore, the work of Hisham Dokainish and colleagues in this issue of , is very welcome. Their study provides a clear picture of clinical cha
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AMG 925 It is well known that the precipitation of solid
2019-04-28

It is well-known that the precipitation of solid cholesterol monohydrate crystals from supersaturated bile is the first irreversible physical-chemical step in gallstone formation. To study the characteristics, metastable intermediates, and kinetics in the phase transitions of bile, a series of phase
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Bile acids are cholesterol derivatives
2019-04-28

Bile acids are cholesterol derivatives produced only in the hepatocytes of the liver. Hepatic bile acid synthesis represents the only quantitatively significant route for cholesterol elimination. Bile acids are amphipathic physiological detergents that facilitate dietary cholesterol, lipid and fat-s
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