• Paclitaxel (Taxol): Next-Gen Cancer Research & Neurotoxic...

  2025-09-27

  Discover the advanced mechanisms of Paclitaxel (Taxol) as a microtubule polymer stabilizer in cancer research, with a special focus on novel approaches to neurotoxicity modeling and mRNA-based intervention. Explore unique scientific perspectives not found in standard reviews.

• SM-164: Unlocking IAP Antagonism for Precision Cancer Res...

  2025-09-26

  Explore how SM-164, a cutting-edge bivalent Smac mimetic and IAP antagonist for cancer therapy, redefines apoptosis induction in tumor cells. This article uniquely integrates recent discoveries in apoptotic signaling, offering advanced insights for cancer research applications.

• NHS-Biotin in Precision Protein Multimerization and Purif...

  2025-09-25

  Explore how NHS-Biotin, a leading amine-reactive biotinylation reagent, is revolutionizing intracellular protein multimerization and purification. This in-depth analysis reveals advanced strategies and addresses technical challenges, providing new solutions for complex biochemical research.

• S63845: Precision MCL1 Inhibition to Decipher Apoptotic N...

  2025-09-24

  Discover how the selective MCL1 inhibitor S63845 empowers advanced hematological cancer research by enabling precise dissection of mitochondrial and combinatorial apoptotic pathways. This article uniquely explores S63845’s mechanistic selectivity, integration with extrinsic modulators, and its frontier role in apoptosis network mapping.

• L1023 Anti-Cancer Compound Library: Accelerating Small Mo...

  2025-09-23

  The L1023 Anti-Cancer Compound Library provides a versatile platform for high-throughput screening of anti-cancer agents, enabling the identification of potent small molecule inhibitors in cancer research. This article examines how the L1023 library can be leveraged for discovering novel therapeutics, with a focus on translational applications in renal cell carcinoma.

• We conducted the largest drug screen to date

  2025-04-22

  

  We conducted the largest drug screen to date in HPV-positive cancers and identified Aurora kinase inhibitors as effective and understudied drugs in HNSCC and CESC. These drugs cause apoptosis and cell cycle arrest in vitro and decrease tumor size in vivo. This is the first published study to demonst

• Matthew et al synthesized and carried out SAR

  2025-04-21

  

  Matthew et al. synthesized and carried out SAR studies of imidazo-[1,2-a]-pyrazine as Aurora kinase inhibitors with enhanced kinase selectivity and found that Z-VAD-FMK 39 showed optimal potency on Aurora-A and Aurora-B with IC50 value of 4 nM and 13 nM while on phosphorylation histone H3 (pHH3), E

• The acidification of endocytic compartments is closely relat

  2025-04-21

  

  The acidification of endocytic compartments is closely related to endocytic activity, although the mechanism linking acidification and membrane dynamics is largely unknown. In a recent RNA interference (RNAi)-based screen, V-ATPase depletion blocked the formation of clathrin-coated vesicles, an effe

• Congruously our findings of voltage electrode clamping assay

  2025-04-19

  

  Congruously, our findings of voltage-electrode-clamping assays indicate that hipN851K mutation mediates partial loss of Na+/K+-ATPase pump currents, also confirming our thesis that hipN851K mutation acts as a hypomorph. As demonstrated here by our external electrical stimulation studies and ECG reco

• It has been shown that

  2025-04-19

  

  It has been shown that ACLY is localized to not only the cytoplasm but also the nucleus. Nuclear ACLY may supply acetyl-CoA for histone acetylation, leading to global regulation of the gene expression [16], [18]. We previously reported that AZ2 is also localized to both the cytoplasm and nucleus whe

• br Materials and methods br Results br Discussion Many

  2025-04-18

  

  Materials and methods Results Discussion Many studies investigate the role of 12/15-LOX in cancer cell,23, 24, 25 however we here first found that host 12/15-LOX also plays an important role in metastasis progression. We have demonstrated that 12(S)-HETE increased melanoma cell adhesion to

• The LOX hydroxide metabolites are

  2025-04-18

  

  The 15-LOX hydroxide metabolites are converted to secondary lipid mediators such as lipoxin A4 from 15-HETE and protectin D1/resolvin D1 from 17-HDoHE [45] (Fig. S3). Importantly, all of these secondary lipid mediators have anti-inflammatory and pro-resolving properties [46], [47], [48]. Lipoxin A4

• ATM dependent initiation of radiation induced G M

  2025-04-17

  

  ATM-dependent initiation of radiation-induced G2/M checkpoint arrest is well established [11], [34], [35]. However, the ATR pathway may also be involved [36], [37]. Brown and Baltimore generated Cre/lox-conditional cell lines or 2X Taq PCR Master Mix (with dye) with a kinase inactive allele of ATR (

• A large number of studies have shown

  2025-04-16

  

  A large number of studies have shown that oxidative stress is involved in the pathophysiological process of ventricular remodeling and is associated with left ventricular dysfunction (Hori and Nishida, 2009, Lord et al., 2010). The generation of reactive oxygen species (ROS) that exceeds anti-oxidat

• Introduction Apoptosis signal regulating kinase ASK a family

  2025-04-15

  

  Introduction Apoptosis signal-regulating kinase 1 (ASK1), a family member of the mitogen-activated protein (MAP) kinase kinase kinase (MAP3K) family, selectively activates the JNK and p38 MAP kinase pathways in response to various types of stresses, including oxidative stress, and subsequently indu

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